GZMA Antikörper (AA 29-262)

Produktnummer ABIN7154414

Produktdetails anti-GZMA Antikörper

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Bindungsspezifität: AA 29-262

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GZMA Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Granzyme A protein (29-262AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu GZMA

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Andere Bezeichnung: GZMA (GZMA Produkte)

Synonyme: gzmA antikoerper, GZMA antikoerper, AW494114 antikoerper, Ctla-3 antikoerper, Ctla3 antikoerper, Hf antikoerper, SE1 antikoerper, TSP-1 antikoerper, TSP1 antikoerper, CTLA3 antikoerper, HFSP antikoerper, granzyme A antikoerper, Granzyme A antikoerper, granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) antikoerper, gzmA antikoerper, GZMA antikoerper, graa antikoerper, Gzma antikoerper

Hintergrund:

Background: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after \\\'Lys-31\\\' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after \\\'Lys-189\\\', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.

Aliases: CTL tryptase antibody, CTLA3 antibody, Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody, Cytotoxic T lymphocyte associated serine esterase 3 antibody, Cytotoxic T lymphocyte proteinase 1 antibody, Cytotoxic T-lymphocyte proteinase 1 antibody, Fragmentin 1 antibody, Fragmentin-1 antibody, GRAA_HUMAN antibody, Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3 antibody, Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3, Hanukah factor serine protease) antibody, Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3) antibody, Granzyme A antibody, Granzyme A precursor antibody, Granzyme-1 antibody, GZMA antibody, H factor antibody, Hanukah factor serine protease antibody, Hanukkah factor antibody, HF antibody, HFSP antibody, TSP1 antibody

UniProt: P12544

Pathways: Apoptose