WEE1 Antikörper (pSer642)
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- Target Alle WEE1 Antikörper anzeigen
- WEE1 (WEE1 Homolog (S. Pombe) (WEE1))
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Bindungsspezifität
- pSer642
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser WEE1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- Immunogen
- Peptide sequence around phosphorylation site of Serine 642(S-V-S(p)-L-T) derived from Human WEE1.
- Isotyp
- IgG
- Top Product
- Discover our top product WEE1 Primärantikörper
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- Applikationshinweise
- WB:1:500-1:1000,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- WEE1 (WEE1 Homolog (S. Pombe) (WEE1))
- Andere Bezeichnung
- WEE1 (WEE1 Produkte)
- Synonyme
- WEE1A antikoerper, WEE1hu antikoerper, ATWEE1 antikoerper, F22D16.3 antikoerper, F22D16_3 antikoerper, WEE1 kinase homolog antikoerper, WEE1-KINASE antikoerper, WEE1 antikoerper, Xe-Wee1B antikoerper, XeWee1B antikoerper, wee1-b antikoerper, wee1a antikoerper, wee2-a antikoerper, xe-wee1a antikoerper, xwee1 antikoerper, wee1 antikoerper, wee1b antikoerper, wee1hu antikoerper, xwee2 antikoerper, GB19689 antikoerper, Wee1A antikoerper, fa20h03 antikoerper, wu:fa20h03 antikoerper, zgc:136514 antikoerper, WEE1 G2 checkpoint kinase antikoerper, Wee1 kinase antikoerper, WEE1-like kinase antikoerper, WEE1 G2 checkpoint kinase S homeolog antikoerper, wee1 homolog antikoerper, WEE1 homolog 2 antikoerper, wee1-like protein kinase antikoerper, WEE 1 homolog 1 (S. pombe) antikoerper, M phase inhibitor protein kinase Wee1 antikoerper, WEE1 antikoerper, Wee1 antikoerper, wee1.S antikoerper, wee1-a antikoerper, wee2 antikoerper, LOC551677 antikoerper, wee1 antikoerper
- Hintergrund
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Background:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Watanabe N., EMBO J. 14:1878-1891(1995).
Cichutek A., Cytogenet. Cell Genet. 93:277-283(2001).
Igarashi M., Nature 353:80-83(1991)Aliases: DKFZp686I18166 antibody, EC 2.7.10.2 antibody, FLJ16446 antibody, MGC105683 antibody, OTTHUMP00000231338 antibody, OTTHUMP00000231339 antibody, Wee 1 antibody, WEE 1 homolog 1 (S. pombe) antibody, WEE1 antibody, WEE1 homolog (S. pombe) antibody, Wee1 homolog antibody, WEE1 homolog S. pombe antibody, Wee1 like protein kinase antibody, Wee1 tyrosine kinase antibody, Wee1+ homolog antibody, Wee1+ S. pombe homolog antibody, WEE1, S. pombe, homolog of antibody, WEE1, somatic antibody, Wee1-like protein kinase antibody, WEE1_HUMAN antibody, WEE1A antibody, Wee1A kinase antibody, WEE1hu antibody
- UniProt
- P30291
- Pathways
- Zellzyklus, Mitotic G1-G1/S Phases, M Phase
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