WEE1 Antikörper (pSer123)

Produktnummer ABIN389681

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-WEE1 Antikörper wird verwendet zum Nachweis von WEE1 in Proben von Human. Er wurde validiert für IHC (p) und DB.

Kurzübersicht für WEE1 Antikörper (pSer123) (ABIN389681)

Target: WEE1 (WEE1 Homolog (S. Pombe) (WEE1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WEE1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

Klon: RB07865

Produktdetails anti-WEE1 Antikörper

Bindungsspezifität: pSer123

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Wee1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S123 of human Wee1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IHC-P: 1:50~100. DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-WEE1 Antikörper (ABIN389681)

Müller, Lutter, Püschel: "Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity." in: Journal of cell science, Vol. 123, Issue Pt 2, pp. 286-94, (2010) (PubMed).

Details zu WEE1

Target: WEE1 (WEE1 Homolog (S. Pombe) (WEE1))

Andere Bezeichnung: Wee1

Hintergrund: This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.

Molekulargewicht: 71597

Gen-ID: 7465

NCBI Accession: NP_001137448, NP_003381

UniProt: P30291

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, M Phase