STAT1 Antikörper (pTyr701)

Produktnummer ABIN7250763

Produktdetails anti-STAT1 Antikörper

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Bindungsspezifität: pTyr701

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktmerkmale: Phosphorylated antibody

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human Stat1 around the phosphorylation site of Tyr701

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300, ELISA 1:5000-1:20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu STAT1

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Andere Bezeichnung: STAT1 (STAT1 Produkte)

Synonyme: CANDF7 antikoerper, ISGF-3 antikoerper, STAT91 antikoerper, 2010005J02Rik antikoerper, AA408197 antikoerper, XStat1 antikoerper, STAT4 antikoerper, DD6G4-4 antikoerper, STAT antikoerper, STAT1 antikoerper, dZ182H3.3 antikoerper, si:by134g18.2 antikoerper, si:by51f19.1 antikoerper, si:dz182h3.3 antikoerper, si:dz199m19.1 antikoerper, si:dz73o4.2 antikoerper, stat1 antikoerper, signal transducer and activator of transcription 1 antikoerper, signal transducer and activator of transcription 1 L homeolog antikoerper, signal transducer and activator of transcription 1, 91kDa antikoerper, signal transducer and activator of transcription 4 antikoerper, signal transducer and activator of transcription 1a antikoerper, STAT1 antikoerper, Stat1 antikoerper, stat1.L antikoerper, stat4 antikoerper, stat1a antikoerper

Hintergrund: Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.

Molekulargewicht:

Observed_MW: 87 kDa

Calculated_MW: 87 kDa

UniProt: P42224

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events