STAT1 Antikörper (C-Term)

Produktnummer ABIN1881847

Produktdetails anti-STAT1 Antikörper

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Bindungsspezifität: AA 717-745, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This STAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 717-745 amino acids from the C-terminal region of human STAT1.

Klon: RB41406

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:1000. IHC-P-Leica: 1:1000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-STAT1 Antikörper (ABIN1881847)

Yang, Shen, Xu, Yang, Tsai, Keng, Chen, Lee: "Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition." in: Scientific reports, Vol. 7, Issue 1, pp. 7958, (2017) (PubMed).

Clarke, Clifford, Jindarat, Proud, Pang, Belvisi, Knox: "TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein." in: The Journal of biological chemistry, Vol. 285, Issue 38, pp. 29101-10, (2010) (PubMed).

Sakamoto, Qin, Navarro, Gamero, Potla, Yi, Zhu, Baker, Feldman, Larner: "Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3245-53, (2004) (PubMed).

Zhang, Cho, Petersen, Zhu, Dong: "Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1." in: Carcinogenesis, Vol. 25, Issue 7, pp. 1165-75, (2004) (PubMed).

Details zu STAT1

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Andere Bezeichnung: STAT1 (STAT1 Produkte)

Synonyme: CANDF7 antikoerper, ISGF-3 antikoerper, STAT91 antikoerper, 2010005J02Rik antikoerper, AA408197 antikoerper, XStat1 antikoerper, STAT4 antikoerper, DD6G4-4 antikoerper, STAT antikoerper, STAT1 antikoerper, dZ182H3.3 antikoerper, si:by134g18.2 antikoerper, si:by51f19.1 antikoerper, si:dz182h3.3 antikoerper, si:dz199m19.1 antikoerper, si:dz73o4.2 antikoerper, stat1 antikoerper, signal transducer and activator of transcription 1 antikoerper, signal transducer and activator of transcription 1 L homeolog antikoerper, signal transducer and activator of transcription 1, 91kDa antikoerper, signal transducer and activator of transcription 4 antikoerper, signal transducer and activator of transcription 1a antikoerper, STAT1 antikoerper, Stat1 antikoerper, stat1.L antikoerper, stat4 antikoerper, stat1a antikoerper

Hintergrund: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq].

Molekulargewicht: 87335

NCBI Accession: NP_009330, NP_644671

UniProt: P42224

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events