SARM1 Antikörper (N-Term)

Produktnummer ABIN6991709

Produktdetails anti-SARM1 Antikörper

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Bindungsspezifität: AA 30-80, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SARM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA

Spezifität: At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. SARM antibody recognize the longest isoform.

Aufreinigung: SARM Antibody is affinity chromatography purified via peptide column.

Immunogen: SARM antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SARM. The immunogen is located within amino acids 30 - 80 of SARM.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SARM antibody can be used for detection of SARM by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SARM Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SARM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SARM1

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Andere Bezeichnung: SARM (SARM1 Produkte)

Synonyme: A830091I15Rik antikoerper, C78606 antikoerper, MyD885 antikoerper, Sarm antikoerper, MyD88-5 antikoerper, SAMD2 antikoerper, SARM antikoerper, sterile alpha and TIR motif containing 1 antikoerper, sterile alpha and HEAT/Armadillo motif containing 1 antikoerper, SARM1 antikoerper, Sarm1 antikoerper, sarm1 antikoerper

Hintergrund: SARM Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-κ,B, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interleukin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.

Gen-ID: 23098

NCBI Accession: NP_055892

UniProt: Q6SZW1

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades