SARM1 Antikörper (C-Term)

Produktnummer ABIN500660

Es sind 2+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-SARM1 Antikörper wird verwendet zum Nachweis von SARM1 in Proben von Human und Maus. Er wurde validiert für WB, IF und EIA.

Kurzübersicht für SARM1 Antikörper (C-Term) (ABIN500660)

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SARM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-SARM1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects SARM1 at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Ion exchange chromatography

Immunogen: SARM antibody was raised against a peptide corresponding to amino acids near the C- terminus of human SARM.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 to 2 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-SARM1 Antikörper (ABIN500660)

Chintala, Putris, Geno: "Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3." in: Investigative ophthalmology & visual science, Vol. 56, Issue 1, pp. 505-14, (2015) (PubMed).

Massoll, Mando, Chintala: "Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons." in: Investigative ophthalmology & visual science, Vol. 54, Issue 4, pp. 2771-80, (2013) (PubMed).

Details zu SARM1

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Andere Bezeichnung: SARM1

Hintergrund: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-kappaB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interluekin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.Synonyms: KIAA0524, SAM domain-containing protein 2, SAMD2, SARM, Sterile alpha and Armadillo repeat protein, Sterile alpha and TIR motif-containing protein 1, Sterile alpha motif domain-containing protein 2

Gen-ID: 23098

NCBI Accession: NP_055892

UniProt: Q6SZW1

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades