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14-3-3 sigma/SFN Antikörper (Internal Region)

SFN Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated

Produktnummer ABIN2744316

Datenblatt (PDF)

Target Alle 14-3-3 sigma/SFN (SFN) Antikörper anzeigen

14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
Bindungsspezifität
15

13

11

9

7

7

7

6

6

3

3

2

2

2

1

1

1

1

1

1
Internal Region
Reaktivität
103

35

28

5

5

5

4

4

4

4

3

1

1

1

1

1
Human, Maus, Ratte
Wirt
93

9

2

1
Kaninchen
Passende Sekundärantikörper
Klonalität
88

17
Polyklonal
Konjugat
48

11

9

6

4

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
Dieser 14-3-3 sigma/SFN Antikörper ist unkonjugiert
Applikation
86

44

38

23

17

15

14

13

13

9

3

2

1

1

1

1

1

1
Western Blotting (WB)

Spezifität

Human SFN / Stratifin / 14-3-3 Sigma

Aufreinigung

Protein A purified

Immunogen

A recombinant protein fragment from the internal region of 14-3-3 sigma.

Type of Immunogen: Recombinant protein

Isotyp

IgG

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Applikationshinweise

Approved: WB (1 - 3 μg/mL)

Usage: 14-3-3 proteins are regulators of a diverse group of signaling proteins, including kinases, phosphatases, and transmembrane receptors, and have roles in a wide range of physiological processes including transcription, intracellular signaling, cell cycle control and apoptosis. There are seven 14-3-3 proteins in most mammals: beta, gamma epsilon, zeta, eta, sigma and tau. 14-3-3 sigma, also called Stratifin, is a product of the SFN gene. It is a tumor suppressor gene inactivated via DNA methylation. Reduced or no expression of 14-3-3 sigma is seen in various carcinoma including skin, breast and prostate, suggesting that 14-3-3 gene silencing may be involved in tumor progression.

Kommentare

Target Species of Antibody: Human

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

Lot specific

Buffer

PBS,  pH 7.4, 0.1 mg/mL BSA, 0.05 % sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

avoid freeze thaw cycles

Lagerung

-20 °C

Informationen zur Lagerung

Store at -20°C. Avoid freeze-thaw cycles.
Target

14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Andere Bezeichnung

SFN / Stratifin / 14-3-3 sigma (SFN Produkte)

Synonyme

YWHAS antikoerper, Er antikoerper, Mme1 antikoerper, Ywhas antikoerper, stratifin antikoerper, SFN antikoerper, Sfn antikoerper

Hintergrund

Name/Gene ID: SFN

Synonyms: SFN, 14-3-3 sigma, 14-3-3 protein sigma, HME1, Stratifin, YWHAS

Gen-ID

2810

Pathways

p53 Signalweg, Myometrial Relaxation and Contraction