XIAP Antikörper

Produktnummer ABIN5966171

Produktdetails anti-XIAP Antikörper

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XIAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human XIAP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000 IHC 1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu XIAP

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Andere Bezeichnung: XIAP (XIAP Produkte)

Synonyme: API3 antikoerper, BIRC4 antikoerper, IAP-3 antikoerper, ILP1 antikoerper, MIHA antikoerper, XLP2 antikoerper, hIAP-3 antikoerper, hIAP3 antikoerper, api3 antikoerper, birc4 antikoerper, ilp1 antikoerper, miha antikoerper, xlp2 antikoerper, xxiap antikoerper, 1110015C02Rik antikoerper, Aipa antikoerper, Api3 antikoerper, Birc4 antikoerper, IAP3 antikoerper, ILP-1 antikoerper, mXIAP antikoerper, riap3 antikoerper, fb73d01 antikoerper, wu:fb73d01 antikoerper, zgc:91873 antikoerper, BIRC8 antikoerper, X-linked inhibitor of apoptosis antikoerper, X-linked inhibitor of apoptosis L homeolog antikoerper, XIAP antikoerper, xiap antikoerper, xiap.L antikoerper, Xiap antikoerper

Hintergrund:

Synonyms: AP 13,API3,Apoptosis Inhibitor 3,Baculoviral IAP repeat containing 4,Baculoviral IAP Repeat Containing Protein 4,Baculoviral IAP repeat-containing protein 4,BIRC 4,BIRC4,E3 ubiquitin-protein ligase XIAP,hIAP-3,hIAP3,HILP,IAP 3,IAP like protein,IAP-3,IAP-like protein,IAP3,ILP 1,ILP,ILP1,Inhibitor of apoptosis protein 3,Inhibitor of Apoptosis X Linked,Mammalian IAP Homologue A,MIHA,X linked IAP,X linked inhibitor of apoptosis,X linked inhibitor of apoptosis E3 ubiquitin protein ligase,X linked inhibitor of apoptosis protein,X-linked IAP,X-linked inhibitor of apoptosis protein,Xiap,XIAP,XLP2

Background: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Molekulargewicht:

Observed_MW: 54kDa

Calculated_MW: 56kDa

Gen-ID: 331

UniProt: P98170

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Transition Metal Ion Homeostasis