CASP5 Antikörper

Produktnummer ABIN643987

Produktdetails anti-CASP5 Antikörper

Target: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CASP5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit Anti-Human CASP5

Spezifität: DS-PB-00380 recognizes an epitope located within the internal region of human Caspase5, a 47kDa cysteine protease, otherwise known as ICH3. Caspase5 has been shown to be expressed at higher levels in the colon, lung, spleen, small intestine and by peripheral blood lymphocytes. Caspase5 is a member of a growing number of inflammatory caspases belonging to the Caspase1 (ICEtype) subfamily, which require proteolytic processing of their inactive precursor into smaller active subunits. Unlike Caspase1, Caspase5 is not directly responsible for the activation of IL1Beta from the proIL1Beta precursor, but the presence of Caspase5 does appear to enhance the processing of IL1Beta. The in vivo expression of Caspase5 is elevated by Lipopolysaccharide (LPS) and gene expression is also increased by Interferon gamma (IFNg). In vitro studies have shown cleavage of Caspase5 by the serine protease Granzyme B, which plays a major role in Cytotoxic T lymphocyte (CTL)induced apoptosis (1).

Produktmerkmale: Phosphorylation/Apoptosis/Signal Transduction/Regulation

Aufreinigung: Purified

Immunogen: Antisera to human Caspase-5 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blotting

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Details zu CASP5

Target: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Andere Bezeichnung: Caspase-5 (CASP5 Produkte)

Synonyme: ICE(rel)III antikoerper, ICEREL-III antikoerper, ICH-3 antikoerper, CASP5 antikoerper, caspase 5 antikoerper, caspase-5 antikoerper, CASP5 antikoerper, LOC100437308 antikoerper

Pathways: Inflammasome