CASP5 Antikörper (Middle Region)

Produktnummer ABIN2787906

Der Kaninchen Polyklonal anti-CASP5 Antikörper wird verwendet zum Nachweis von CASP5 in Proben von Human, Rind (Kuh) und Meerschweinchen. Er wurde validiert für WB und FACS.

Kurzübersicht für CASP5 Antikörper (Middle Region) (ABIN2787906)

Target: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Reaktivität: Human, Rind (Kuh), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CASP5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-CASP5 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: CASP5 Antibody - middle region

Sequenz: VIIVQACRGE KHGELWVRDS PASLALISSQ SSENLEADSV CKIHEEKDFI

Homologie: Cow: 83%, Guinea Pig: 82%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CASP5. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CASP5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58992-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu CASP5

Target: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Andere Bezeichnung: CASP5

Hintergrund:

Background Information: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.

Gene Name: Caspase 5, apoptosis-related cysteine peptidase

Alternative Symbols: ICH-3, ICEREL-III, ICE(rel)III

Protein Name: Caspase-5

Molekulargewicht: 43kDa

Gen-ID: 838

NCBI Accession: NP_001129581

UniProt: P51878

Pathways: Inflammasome