TRAIL Antikörper

Produktnummer ABIN640733

Produktdetails anti-TRAIL Antikörper

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRAIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit Anti-Human CD253

Spezifität: DS-PB-02541 is specific for human CD253, otherwise known as TRAIL or Apo2L, a 281 amino acid type II transmembrane glycoprotein and member of the tumor necrosis factor superfamily, which induces apoptosis in tumor and transformed cells, but not normal cells. Activation of apoptosis by CD253 occurs through binding to the death-signaling receptors DR4 (TRAILR1) and DR5 (TRAILR2), leading to formation of the death-inducing signaling complex (DISC) and the triggering of a proteolytic caspase cascade. There are however decoy receptors known as DcR1 (TRAILR3) and DcR2 (TRAILR4) which competitively bind to CD253 and are unable to initiate apoptosis. CD253 also plays a role in immune surveillance, acting as a mediator of monocyte, NK cell, dendritic cell and T cell anti-tumor and anti-viral cytotoxicity.

Produktmerkmale: Adhesion Molecule/Cell Surface

Aufreinigung: Purified

Immunogen: Antisera to human CD253 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA (dilution: 0.1, 0.2 μg/mL), Immunohistology - Paraffin, Western Blotting

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Reconstitute with 0.1 mL distilled water. For long term storage the addition of 0.09 % sodium azide is recommended.

Konzentration: IgG concentration 1.0 mg/ml after reconstitution

Buffer: Phosphate buffered saline pH7.4

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Details zu TRAIL

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Andere Bezeichnung: CD253 (TNFSF10 Produkte)

Synonyme: APO2L antikoerper, Apo-2L antikoerper, CD253 antikoerper, TL2 antikoerper, TRAIL antikoerper, A330042I21Rik antikoerper, AI448571 antikoerper, APO-2L antikoerper, Ly81 antikoerper, Trail antikoerper, tl2 antikoerper, apo2l antikoerper, cd253 antikoerper, trail antikoerper, apo-2l antikoerper, trail1 antikoerper, xtrail1 antikoerper, tnfsf10l2 antikoerper, zgc:92320 antikoerper, TNLG6A antikoerper, TNF superfamily member 10 antikoerper, tumor necrosis factor (ligand) superfamily, member 10 antikoerper, tumor necrosis factor superfamily member 10 antikoerper, TNF superfamily member 10 S homeolog antikoerper, TNFSF10 antikoerper, Tnfsf10 antikoerper, tnfsf10.S antikoerper, tnfsf10 antikoerper

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity