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TRAIL Antikörper (AA 95-281) (PE)

TNFSF10 Reaktivität: Human FACS Wirt: Maus Monoclonal 2E5 PE
Produktnummer ABIN1690743
  • Target Alle TRAIL (TNFSF10) Antikörper anzeigen
    TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
    Bindungsspezifität
    • 15
    • 8
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 95-281
    Reaktivität
    • 105
    • 36
    • 31
    • 4
    • 2
    Human
    Wirt
    • 79
    • 43
    • 5
    Maus
    Klonalität
    • 82
    • 45
    Monoklonal
    Konjugat
    • 71
    • 16
    • 10
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TRAIL Antikörper ist konjugiert mit PE
    Applikation
    • 92
    • 35
    • 27
    • 24
    • 13
    • 13
    • 10
    • 9
    • 9
    • 8
    • 8
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The antibody 2E5 reacts with an extracellular epitope within C-terminal half of TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues.
    Keine Kreuzreaktivität
    Maus
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    Recombinant soluble fragment (aa 95-281) of human TRAIL.
    Klon
    2E5
    Isotyp
    IgG1
    Top Product
    Discover our top product TNFSF10 Primärantikörper
  • Applikationshinweise
    Flow cytometry: Recommended dilution: 1-5 μg/mL.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.1 mg/mL
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Hyer, Croxton, Krajewska, Krajewski, Kress, Lu, Suh, Sporn, Cryns, Zapata, Reed: "Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells." in: Cancer research, Vol. 65, Issue 11, pp. 4799-808, (2005) (PubMed).

    Plasilova, Zivny, Jelinek, Neuwirtova, Cermak, Necas, Andera, Stopka: "TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors." in: Leukemia, Vol. 16, Issue 1, pp. 67-73, (2002) (PubMed).

  • Target
    TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
    Andere Bezeichnung
    CD253 / TRAIL (TNFSF10 Produkte)
    Synonyme
    APO2L antikoerper, Apo-2L antikoerper, CD253 antikoerper, TL2 antikoerper, TRAIL antikoerper, A330042I21Rik antikoerper, AI448571 antikoerper, APO-2L antikoerper, Ly81 antikoerper, Trail antikoerper, tl2 antikoerper, apo2l antikoerper, cd253 antikoerper, trail antikoerper, apo-2l antikoerper, trail1 antikoerper, xtrail1 antikoerper, tnfsf10l2 antikoerper, zgc:92320 antikoerper, TNLG6A antikoerper, TNF superfamily member 10 antikoerper, tumor necrosis factor (ligand) superfamily, member 10 antikoerper, tumor necrosis factor superfamily member 10 antikoerper, TNF superfamily member 10 S homeolog antikoerper, TNFSF10 antikoerper, Tnfsf10 antikoerper, tnfsf10.S antikoerper, tnfsf10 antikoerper
    Hintergrund
    TNF superfamily member 10,Human CD253 / TRAIL (TNF-related apoptosis inducing ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2).,TRAIL, Apo-2 ligand, Apo-2L, TNFSF10, APO2L, TNLG6A
    Gen-ID
    8743
    UniProt
    P50591
    Pathways
    Apoptose, Positive Regulation of Endopeptidase Activity
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