ABL1 Antikörper (pTyr245)
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- Target Alle ABL1 Antikörper anzeigen
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
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Bindungsspezifität
- AA 170-250, pTyr245
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ABL1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Verwendungszweck
- c-Abl is a protein encoded by the ABL1 gene which is approximately 122,8 kDa. c-Abl is localised to the cytoplasm, nucleus and mitochondrion. It is involved in DNA double-strand break repair, development Slit-Robo signalling, cell cycle and the ErbB signalling pathway. It coordinates actin re-modelling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like branch formation, membrane anchoring, signalling and microtubule-binding proteins. c-Abl is widely expressed in human tissues. Mutations in the ABL1 gene result in chronic myeloid leukemia. STJ90694 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous c-Abl protein which only binds about Y245 when Y245 is phosphorylated.
- Spezifität
- Phospho-c-Abl (Y245) Polyclonal Antibody detects endogenous levels of c-Abl protein only when phosphorylated at Y245.
- Produktmerkmale
- Rabbit polyclonal to Phospho-c-Abl (Y245).
- Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- Synthesized peptide derived from human c-Abl around the phosphorylation site of Y245.
- Isotyp
- IgG
- Top Product
- Discover our top product ABL1 Primärantikörper
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- Applikationshinweise
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WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:5000 - Kommentare
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Widely expressed.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Target
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
- Andere Bezeichnung
- c-Abl (ABL1 Produkte)
- Synonyme
- ABL antikoerper, JTK7 antikoerper, bcr/abl antikoerper, c-ABL antikoerper, p150 antikoerper, v-abl antikoerper, AI325092 antikoerper, Abl antikoerper, E430008G22Rik antikoerper, c-Abl antikoerper, ABL proto-oncogene 1, non-receptor tyrosine kinase antikoerper, c-abl oncogene 1, non-receptor tyrosine kinase antikoerper, Tyrosine-protein kinase abl-1 antikoerper, ABL1 antikoerper, Abl1 antikoerper, abl-1 antikoerper, abl1 antikoerper
- Molekulargewicht
- 120 kDa
- Gen-ID
- 25
- UniProt
- P00519
- Pathways
- Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism
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