DR4 Antikörper

Produktnummer ABIN6265699

Produktdetails anti-DR4 Antikörper

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: TR10A antibody detects endogenous levels of total TR10A

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TR10A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500~1:3000, IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Referenzen für anti-DR4 Antikörper (ABIN6265699)

Luo, Pan, Liu, Yuan, Yan: "Sphingomyelin synthase 2 overexpression promotes cisplatin-induced apoptosis of HepG2 cells." in: Oncology letters, Vol. 15, Issue 1, pp. 483-488, (2018) (PubMed).

Details zu DR4

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Andere Bezeichnung: TR10A (DR4 Produkte)

Synonyme: APO2 antikoerper, CD261 antikoerper, DR4 antikoerper, TRAILR-1 antikoerper, TRAILR1 antikoerper, TNF receptor superfamily member 10a antikoerper, TNFRSF10A antikoerper

Hintergrund:

Description: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Gene: TNFRSF10A

Molekulargewicht: 50kDa

Gen-ID: 8797

UniProt: O00220

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity