PLK4 Antikörper

Produktnummer ABIN6264303

Produktdetails anti-PLK4 Antikörper

Target: PLK4 (Polo-Like Kinase 4 (PLK4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: PLK4 Antibody detects endogenous levels of total PLK4

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PLK4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu PLK4

Target: PLK4 (Polo-Like Kinase 4 (PLK4))

Andere Bezeichnung: PLK4 (PLK4 Produkte)

Synonyme: CG7186 antikoerper, DmSAK antikoerper, Dmel\\CG7186 antikoerper, PLK4 antikoerper, Plk4 antikoerper, SAK/PLK antikoerper, SAK/PLK4 antikoerper, Sak antikoerper, plk4 antikoerper, sak antikoerper, SAK antikoerper, STK18 antikoerper, 1700028H20 antikoerper, AI385771 antikoerper, Stk18 antikoerper, PLK-4 antikoerper, stk18 antikoerper, wu:fi33g07 antikoerper, Sak kinase antikoerper, polo like kinase 4 antikoerper, polo-like kinase 4 antikoerper, polo-like kinase 4 (Drosophila) antikoerper, serine/threonine-protein kinase PLK4 antikoerper, SAK antikoerper, PLK4 antikoerper, Plk4 antikoerper, plk4 antikoerper, LOC5571876 antikoerper

Substanzklasse: Phage Protein

Hintergrund:

Description: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).

Gene: PLK4

Molekulargewicht: 95 kDa

Gen-ID: 10733

UniProt: O00444

Pathways: M Phase