PLK4 Antikörper (AA 724-758)

Produktnummer ABIN6243950

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PLK4 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PLK4 Antikörper (AA 724-758) (ABIN6243950)

Target: PLK4 (Polo-Like Kinase 4 (PLK4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB53118

Produktdetails anti-PLK4 Antikörper

Bindungsspezifität: AA 724-758

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PLK4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 724-758 amino acids from the region of human PLK4.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu PLK4

Target: PLK4 (Polo-Like Kinase 4 (PLK4))

Andere Bezeichnung: PLK4

Substanzklasse: Phage Protein

Hintergrund: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2.

Molekulargewicht: 108972

UniProt: O00444

Pathways: M Phase