ARL6 Antikörper (Internal Region)

Produktnummer ABIN6260210

Produktdetails anti-ARL6 Antikörper

Target: ARL6 (ADP Ribosylation Factor Like GTPase 6 (ARL6))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARL6 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Spezifität: BBS3 Antibody detects endogenous levels of total BBS3.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BBS3, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ARL6

Target: ARL6 (ADP Ribosylation Factor Like GTPase 6 (ARL6))

Andere Bezeichnung: ARL6 (ARL6 Produkte)

Synonyme: BBS3 antikoerper, RP55 antikoerper, 1110018H24Rik antikoerper, 2210411E14Rik antikoerper, zgc:101762 antikoerper, arl6 antikoerper, ADP ribosylation factor like GTPase 6 antikoerper, ADP-ribosylation factor-like 6 antikoerper, ADP-ribosylation factor like GTPase 6 antikoerper, ADP-ribosylation factor-like protein 6 antikoerper, ADP ribosylation factor like GTPase 6 L homeolog antikoerper, ARL6 antikoerper, Arl6 antikoerper, arl6 antikoerper, arl-6 antikoerper, arl6.L antikoerper

Hintergrund:

Description: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729). Isoform 2 may be required for proper retinal function and organization (By similarity).

Gene: ARL6

Molekulargewicht: 21 kDa

Gen-ID: 84100

UniProt: Q9H0F7