ARL6 Antikörper (N-Term)

Produktnummer ABIN1882064

Produktdetails anti-ARL6 Antikörper

Target: ARL6 (ADP Ribosylation Factor Like GTPase 6 (ARL6))

Bindungsspezifität: AA 1-30, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARL6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ARL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ARL6.

Klon: RB4921

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ARL6 Antikörper (ABIN1882064)

Wiens, Tong, Esmail, Oh, Gerdes, Wang, Tempel, Rattner, Katsanis, Park, Leroux: "Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling." in: The Journal of biological chemistry, Vol. 285, Issue 21, pp. 16218-30, (2010) (PubMed).

Pasqualato, Renault, Cherfils: "Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication." in: EMBO reports, Vol. 3, Issue 11, pp. 1035-41, (2002) (PubMed).

Ingley, Williams, Walker, Tsai, Colley, Sayer, Tilbrook, Sarna, Beaumont, Klinken: "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit." in: FEBS letters, Vol. 459, Issue 1, pp. 69-74, (1999) (PubMed).

Jacobs, Schilf, Fliegert, Koling, Weber, Schürmann, Joost: "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal." in: FEBS letters, Vol. 456, Issue 3, pp. 384-8, (1999) (PubMed).

Details zu ARL6

Target: ARL6 (ADP Ribosylation Factor Like GTPase 6 (ARL6))

Andere Bezeichnung: ARL6 (ARL6 Produkte)

Synonyme: BBS3 antikoerper, RP55 antikoerper, 1110018H24Rik antikoerper, 2210411E14Rik antikoerper, zgc:101762 antikoerper, arl6 antikoerper, ADP ribosylation factor like GTPase 6 antikoerper, ADP-ribosylation factor-like 6 antikoerper, ADP-ribosylation factor like GTPase 6 antikoerper, ADP-ribosylation factor-like protein 6 antikoerper, ADP ribosylation factor like GTPase 6 L homeolog antikoerper, ARL6 antikoerper, Arl6 antikoerper, arl6 antikoerper, arl-6 antikoerper, arl6.L antikoerper

Hintergrund: ARL6 belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described.

Molekulargewicht: 21097

NCBI Accession: NP_001265222, NP_115522, NP_816931

UniProt: Q9H0F7