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SQSTM1 Antikörper (pSer403)

SQSTM1 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6274065
  • Target Alle SQSTM1 Antikörper anzeigen
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Bindungsspezifität
    • 19
    • 17
    • 15
    • 13
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer403
    Reaktivität
    • 151
    • 64
    • 61
    • 18
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 125
    • 24
    • 1
    • 1
    Kaninchen
    Klonalität
    • 127
    • 24
    Polyklonal
    Konjugat
    • 72
    • 11
    • 10
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SQSTM1 Antikörper ist unkonjugiert
    Applikation
    • 102
    • 58
    • 39
    • 38
    • 22
    • 16
    • 16
    • 14
    • 14
    • 13
    • 9
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Spezifität
    Phospho-SQSTM1/p62 (Ser403) Antibody detects endogenous levels of SQSTM1/p62 only when phosphorylated at Ser403.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human SQSTM1/p62 around the phosphorylation site of Ser403.
    Isotyp
    IgG
    Top Product
    Discover our top product SQSTM1 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Zhou, Hao, Wang, Xu: "Cereblon suppresses the formation of pathogenic protein aggregates in a p62-dependent manner." in: Human molecular genetics, Vol. 27, Issue 4, pp. 667-678, (2018) (PubMed).

  • Target
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Andere Bezeichnung
    SQSTM1 (SQSTM1 Produkte)
    Synonyme
    SQSTM1 antikoerper, sqstm1 antikoerper, MGC79491 antikoerper, A170 antikoerper, OSIL antikoerper, PDB3 antikoerper, ZIP3 antikoerper, p60 antikoerper, p62 antikoerper, p62B antikoerper, OSF-6 antikoerper, Osi antikoerper, STAP antikoerper, ZIP antikoerper, sb:cb621 antikoerper, zgc:85784 antikoerper, sequestosome 1 antikoerper, sequestosome 1 L homeolog antikoerper, SQSTM1 antikoerper, sqstm1 antikoerper, Sqstm1 antikoerper, sqstm1.L antikoerper
    Hintergrund

    Description: Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102).

    Gene: SQSTM1

    Molekulargewicht
    62kDa
    Gen-ID
    8878
    UniProt
    Q13501
    Pathways
    NF-kappaB Signalweg, Neurotrophin Signalübertragung, Autophagie
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