MALT1 Antikörper (AA 701-808) (Biotin)
-
- Target Alle MALT1 Antikörper anzeigen
- MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))
-
Bindungsspezifität
- AA 701-808
-
Reaktivität
- Human
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser MALT1 Antikörper ist konjugiert mit Biotin
-
Applikation
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Verwendungszweck
- Mouse Monoclonal anti-MALT-1 (MT1/410), Biotin Conjugate
- Produktmerkmale
- Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11,18)(q21,q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogen
- Human MALT1 recombinant fragment (aa701-808)
- Klon
- MT1-410
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product MALT1 Primärantikörper
-
-
- Applikationshinweise
-
Western blotting 0.5-1 μg/mL, Immunohistology formalin-fixed 0.5-1 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Optimal dilution for a specific application should be determined by user
- Kommentare
-
Jurkat, Daudi or HeLa cells. Tonsil or lymphoma.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
- Target
- MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))
- Andere Bezeichnung
- MALT-1 (MALT1 Produkte)
- Synonyme
- malt1 antikoerper, MALT1 antikoerper, mlt antikoerper, mlt1 antikoerper, MLT antikoerper, MLT1 antikoerper, A630046N12 antikoerper, D430033E09Rik antikoerper, MALT paracaspase 2 antikoerper, MALT1 paracaspase antikoerper, MALT1 paracaspase S homeolog antikoerper, paracaspase 3 antikoerper, malt2 antikoerper, MALT1 antikoerper, malt1.S antikoerper, Malt1 antikoerper, PCASP3 antikoerper
- Hintergrund
- Caspase-like protein, MALT lymphoma-associated translocation, MLT1, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Paracaspase
- Molekulargewicht
- 93 kDa
- Gen-ID
- 10892, 601217
- UniProt
- Q9UDY8
- Pathways
- T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine
-