CDC25B Antikörper (pSer149)

Produktnummer ABIN616043

Produktdetails anti-CDC25B Antikörper

Target: CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))

Bindungsspezifität: pSer149

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC25B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: F-R-S(p)-L-P

Spezifität: This antibody detects endogenous level of Cdc25B protein only when phosphorylated at serine 149.

Kreuzreaktivität (Details): Species reactivity (tested):Mouse, rat

Aufreinigung: Affinity-chromatography using epitope-specific peptide

Immunogen: Peptide sequence around phosphorylation site of Serine 149 derived from Mouse Cdc25B.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C.

Details zu CDC25B

Target: CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))

Andere Bezeichnung: Cdc25B (CDC25B Produkte)

Synonyme: CDC25B antikoerper, AI604853 antikoerper, cell division cycle 25B antikoerper, cdc25b antikoerper, CDC25B antikoerper, Cdc25b antikoerper

Hintergrund: Cdc25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.

Gen-ID: 12531

NCBI Accession: NP_001104545

UniProt: Q9DBN8

Pathways: Zellzyklus, M Phase, Autophagie