PPM1D Antikörper (AA 1-250)

Produktnummer ABIN6146041

Produktdetails anti-PPM1D Antikörper

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Bindungsspezifität: AA 1-250

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPM1D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPTAEEKPS PRRSLSQPLP PRPSPAALPG GEVSGKGPAV AAREARDPLP DAGASPAPSR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL WGFIKKQKGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII RGMKMYVAHV GDSGVVLGIQ DDPKDDFVRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG VNRVVWKRPR

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PPM1D (NP_003611.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PPM1D

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Andere Bezeichnung: PPM1D (PPM1D Produkte)

Synonyme: PP2C-DELTA antikoerper, WIP1 antikoerper, AV338790 antikoerper, Wip1 antikoerper, zgc:103518 antikoerper, ppm1d antikoerper, wu:fj44c08 antikoerper, zgc:55836 antikoerper, zgc:77316 antikoerper, protein phosphatase, Mg2+/Mn2+ dependent 1D antikoerper, protein phosphatase 1D magnesium-dependent, delta isoform antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1D antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1Db antikoerper, protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1Da antikoerper, PPM1D antikoerper, Ppm1d antikoerper, ppm1db antikoerper, ppm1d.L antikoerper, ppm1da antikoerper

Hintergrund: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.,PPM1D,PP2C-DELTA,WIP1,IDDGIP,Cancer,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cell Cycle,G2/M DNA Damage Checkpoint,PPM1D

Molekulargewicht: 47 kDa/66 kDa

Gen-ID: 8493

UniProt: O15297

Pathways: p53 Signalweg, Zellzyklus