COM1 antikoerper, CTIP antikoerper, JWDS antikoerper, RIM antikoerper, SAE2 antikoerper, SCKL2 antikoerper, 9930104E21Rik antikoerper, CtIP antikoerper, RBBP-8 antikoerper, RGD1308872 antikoerper, RBBP8 antikoerper, DKFZp469K0714 antikoerper, RB binding protein 8, endonuclease antikoerper, retinoblastoma binding protein 8, endonuclease antikoerper, retinoblastoma binding protein 8 L homeolog antikoerper, retinoblastoma binding protein 8 antikoerper, RBBP8 antikoerper, Rbbp8 antikoerper, rbbp8.L antikoerper, rbbp8 antikoerper
Hintergrund
Synonyms:CTIP Background:Endonuclease that cooperates with the MRE11-RAD50-NBN(MRN) complex in processing meiotic and mitotic double-strand breaks(DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining(A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.