WEE1 Antikörper (AA 202-230)

Produktnummer ABIN5537401

Produktdetails anti-WEE1 Antikörper

Target: WEE1 (WEE1 Homolog (S. Pombe) (WEE1))

Bindungsspezifität: AA 202-230

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WEE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Wee1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-230 amino acids from the Central region of mouse Wee1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu WEE1

Target: WEE1 (WEE1 Homolog (S. Pombe) (WEE1))

Andere Bezeichnung: Wee1 (WEE1 Produkte)

Synonyme: WEE1A antikoerper, WEE1hu antikoerper, ATWEE1 antikoerper, F22D16.3 antikoerper, F22D16_3 antikoerper, WEE1 kinase homolog antikoerper, WEE1-KINASE antikoerper, WEE1 antikoerper, Xe-Wee1B antikoerper, XeWee1B antikoerper, wee1-b antikoerper, wee1a antikoerper, wee2-a antikoerper, xe-wee1a antikoerper, xwee1 antikoerper, wee1 antikoerper, wee1b antikoerper, wee1hu antikoerper, xwee2 antikoerper, GB19689 antikoerper, Wee1A antikoerper, fa20h03 antikoerper, wu:fa20h03 antikoerper, zgc:136514 antikoerper, WEE1 G2 checkpoint kinase antikoerper, Wee1 kinase antikoerper, WEE1-like kinase antikoerper, WEE1 G2 checkpoint kinase S homeolog antikoerper, wee1 homolog antikoerper, WEE1 homolog 2 antikoerper, wee1-like protein kinase antikoerper, WEE 1 homolog 1 (S. pombe) antikoerper, M phase inhibitor protein kinase Wee1 antikoerper, WEE1 antikoerper, Wee1 antikoerper, wee1.S antikoerper, wee1-a antikoerper, wee2 antikoerper, LOC551677 antikoerper, wee1 antikoerper

Hintergrund: Wee1 may act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (By similarity).

Molekulargewicht: 72 kDa

Gen-ID: 22390

UniProt: P47810

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, M Phase