FEN1 Antikörper (AA 243-272)

Produktnummer ABIN5534280

Produktdetails anti-FEN1 Antikörper

Target: FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))

Bindungsspezifität: AA 243-272

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FEN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This FEN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the Central region of human FEN1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For IF starting dilution is: 1:100

For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu FEN1

Target: FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))

Andere Bezeichnung: FEN1 (FEN1 Produkte)

Synonyme: FEN-1 antikoerper, FEN1 antikoerper, AW538437 antikoerper, MF1 antikoerper, RAD2 antikoerper, cb879 antikoerper, fen-1 antikoerper, fen1 antikoerper, mf1 antikoerper, rad2 antikoerper, xFEN1a antikoerper, flap structure-specific endonuclease 1 antikoerper, flap endonuclease 1-like antikoerper, Flap endonuclease-1 antikoerper, 5'-3' exonuclease family protein antikoerper, flap structure specific endonuclease 1 antikoerper, flap structure-specific endonuclease 1 L homeolog antikoerper, nuclease, Rad2 family antikoerper, FEN1 antikoerper, LOC100808044 antikoerper, Bm1_49605 antikoerper, AT5G26680 antikoerper, Fen1 antikoerper, fen1 antikoerper, fen1.L antikoerper

Hintergrund: FEN1 removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. This protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

Molekulargewicht: 43 kDa

Gen-ID: 2237

UniProt: P39748

Pathways: Telomere Maintenance, DNA Reparatur, DNA Replication, Synthesis of DNA