FEN1 Produkte
(Flap Structure-Specific Endonuclease 1 (FEN1))
Kategorien
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008].
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Ausgewählte FEN1 Kategorien
FEN1 Antikörper
High quality antibodies with extensive validation data.
FEN1 ELISA Kits
Reliable ELISA kits for a wide range of species.
FEN1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene FEN1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF, IP, IHC (p), ICC, PLA
Validierungen
- (6)
Kat. Nr.
ABIN2855166
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF, IP
Validierungen
- (6)
Kat. Nr.
ABIN3021632
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IHC, IF
Validierungen
- (5)
Kat. Nr.
ABIN7255764
Menge
200 μL
Datenblatt
Datenblatt
Empfohlene FEN1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6955927
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1133432
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6217033
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene FEN1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1353955
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1353954
Menge
25 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3092557
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren FEN1 Produkten
: "Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response." in: International journal of biological sciences, Vol. 12, Issue 4, pp. 466-77, (2016) (PubMed).: "Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication." in: The Journal of biological chemistry, Vol. 287, Issue 26, pp. 21980-91, (2012) (PubMed).
: "Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function." in: Neoplasia (New York, N.Y.), Vol. 14, Issue 6, pp. 495-508, (2012) (PubMed).
: "Prostate cancer cell lines under hypoxia exhibit greater stem-like properties." in: PLoS ONE, Vol. 6, Issue 12, pp. e29170, (2012) (PubMed).
: "Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair." in: The Journal of biological chemistry, Vol. 286, Issue 37, pp. 31975-83, (2011) (PubMed).
: "Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity." in: Biochemistry, Vol. 50, Issue 11, pp. 1901-9, (2011) (PubMed).
: "DNA polymerase beta-dependent long patch base excision repair in living cells." in: DNA repair, Vol. 9, Issue 2, pp. 109-19, (2010) (PubMed).
: "FEN1 ensures telomere stability by facilitating replication fork re-initiation." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27057-66, (2010) (PubMed).
: "Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding." in: Nature chemical biology, Vol. 6, Issue 10, pp. 766-73, (2010) (PubMed).
: "Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance." in: The Journal of biological chemistry, Vol. 284, Issue 6, pp. 3682-90, (2009) (PubMed).
Synonyme und alternative Namen zu FEN1
flap structure-specific endonuclease 1 (FEN1), flap endonuclease 1-like (LOC100808044), Flap endonuclease-1 (Bm1_49605), 5'-3' exonuclease family protein (AT5G26680), flap structure specific endonuclease 1 (Fen1), flap structure-specific endonuclease 1 (fen1), flap structure-specific endonuclease 1 L homeolog (fen1.L), flap structure-specific endonuclease 1 (Fen1), nuclease, Rad2 family (FEN1), AW538437, cb879, FEN-1, fen-1, FEN1, fen1, MF1, mf1, RAD2, rad2, xFEN1aBezeichner auf Proteinebene für FEN1
- flap endonuclease 1
- Flap structure-specific endonuclease 1
- flap structure-specific endonuclease 1
- DNase IV
- maturation factor 1
- maturation factor-1
- 5' nuclease xFEN1a
- FEN-1-A
- flap endonuclease 1-A
- flap structure-specific endonuclease 1-A
- xFEN-1a
- FEN-1
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