FE65 Produkte
(Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
Kategorien
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012].
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Ausgewählte FE65 Kategorien
FE65 Antikörper
High quality antibodies with extensive validation data.
FE65 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene FE65 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN3043784
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7144040
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse, Rat
Applikation
WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro)
Validierungen
- (2)
Kat. Nr.
ABIN725075
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene FE65 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1345278
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1345280
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1345282
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren FE65 Produkten
: "Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation." in: Scientific reports, Vol. 5, pp. 11529, (2015) (PubMed).: "Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development." in: The EMBO journal, Vol. 25, Issue 2, pp. 420-31, (2006) (PubMed).
: "FE65 interaction with the ApoE receptor ApoEr2." in: The Journal of biological chemistry, Vol. 281, Issue 34, pp. 24521-30, (2006) (PubMed).
: "Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)." in: Molecular biology of the cell, Vol. 18, Issue 1, pp. 201-10, (2006) (PubMed).
: "The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 41182-8, (2003) (PubMed).
: "The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway." in: Biochemistry, Vol. 42, Issue 12, pp. 3627-34, (2003) (PubMed).
: "gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins." in: Biochemistry, Vol. 42, Issue 22, pp. 6664-73, (2003) (PubMed).
: "A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60." in: Science (New York, N.Y.), Vol. 293, Issue 5527, pp. 115-20, (2001) (PubMed).
Synonyme und alternative Namen zu FE65
amyloid beta precursor protein binding family B member 1 (APBB1), amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog (apbb1.L), amyloid beta (A4) precursor protein-binding, family B, member 1 (Apbb1), amyloid beta precursor protein binding family B member 1 (Apbb1), apbb1, FE65, Fe65, MGC80654, MGC:9072, RIR, RirBezeichner auf Proteinebene für FE65
- adaptor protein FE65a2
- amyloid beta A4 precursor protein-binding family B member 1
- stat-like protein
- amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
- amyloid beta A4 precursor protein-binding, family B, member 1
- amyloid beta precursor protein-binding B1
- amyloid beta A4 precursor protein-binding family B member 1-like
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