FE65 Antikörper (AA 361-710)

Produktnummer ABIN7144040

Produktdetails anti-FE65 Antikörper

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Bindungsspezifität: AA 361-710

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FE65 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Amyloid beta A4 precursor protein-binding family B member 1 protein (361-710AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FE65

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Andere Bezeichnung: APBB1 (APBB1 Produkte)

Synonyme: FE65 antikoerper, MGC:9072 antikoerper, RIR antikoerper, apbb1 antikoerper, MGC80654 antikoerper, Fe65 antikoerper, Rir antikoerper, amyloid beta precursor protein binding family B member 1 antikoerper, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog antikoerper, amyloid beta (A4) precursor protein-binding, family B, member 1 antikoerper, APBB1 antikoerper, apbb1.L antikoerper, Apbb1 antikoerper

Hintergrund:

Background: Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on \\\'Tyr-142\\\' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).

Aliases: Adaptor protein FE65a2 antibody, Amyloid beta (A4) precursor protein binding family B member 1 antibody, Amyloid beta A4 precursor protein binding family B antibody, Amyloid beta A4 precursor protein binding family B member 1 antibody, Amyloid beta A4 precursor protein-binding family B member 1 antibody, Amyloid beta precursor protein binding family B member 1 antibody, APBB 1 antibody, APBB1 antibody, APBB1_HUMAN antibody, FE 65 antibody, Fe65 protein antibody, Protein Fe65 antibody, RIR antibody, stat like protein antibody

UniProt: O00213

Pathways: Positive Regulation of Response to DNA Damage Stimulus