SPHK1 Antikörper (AA 286-315)

Produktnummer ABIN5532142

Produktdetails anti-SPHK1 Antikörper

Target: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Bindungsspezifität: AA 286-315

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPHK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SPHK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the Central region of human SPHK1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For IHC-P starting dilution is: 1:25

For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.36 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SPHK1

Target: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Andere Bezeichnung: SPHK1 (SPHK1 Produkte)

Synonyme: CG1747 antikoerper, Dmel\\CG1747 antikoerper, SK1 antikoerper, Sphk1 antikoerper, SPHK1 antikoerper, F18E5.160 antikoerper, F18E5_160 antikoerper, sphingosine kinase 1 antikoerper, SPHK antikoerper, 1110006G24Rik antikoerper, Sk1 antikoerper, Spk1 antikoerper, Sphingosine kinase 1 antikoerper, sphingosine kinase 1 antikoerper, sphingosine kinase 1 L homeolog antikoerper, Sk1 antikoerper, SPHK1 antikoerper, sphk1.L antikoerper, Sphk1 antikoerper

Hintergrund: Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.

Molekulargewicht: 43 kDa

Gen-ID: 8877

UniProt: Q9NYA1

Pathways: VEGF Signaling