Sphingosine Kinase 1 (SPHK1) (AA 1-384) Antikörper

Details zu Produkt Nr. ABIN522355
Antigen
  • CG1747
  • Dmel\\CG1747
  • SK1
  • Sphk1
  • SPHK1
  • F18E5.160
  • F18E5_160
  • sphingosine kinase 1
  • SPHK
  • 1110006G24Rik
  • Sk1
  • Spk1
  • Sphingosine kinase 1
  • sphingosine kinase 1
  • sphingosine kinase 1 L homeolog
  • Sk1
  • SPHK1
  • sphk1.L
  • Sphk1
Epitop
AA 1-384
31
18
15
10
8
7
7
7
6
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
196
82
73
14
6
3
3
2
2
1
1
1
1
1
1
Wirt
Maus
184
17
9
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
9
7
5
5
5
5
4
4
4
4
4
4
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
141
67
60
38
26
13
11
10
7
5
4
3
2
Optionen
Immunogen SPHK1 (AAH08040, 1 a.a. ~ 384 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen sequence: MDPAGGPRGV LPRPCRVLVL LNPRGGKGKA LQLFRSHVQP LLAEAEISFT LMLTERRNHA RELVRSEELG RWDALVVMSG DGLMHEVVNG LMERPDWETA IQKPLCSLPA GSGNALAASL NHYAGYEQVT NEDLLTNCTL LLCRRLLSPM NLLSLHTASG LRLFSVLSLA WGFIADVDLE SEKYRRLGEM RFTLGTFLLL AALRTYRGRL AYLPVGRVGS KTPASPVVVQ QGPVDAHLVP LEEPVPSHWT VVPDEDFVLV LALLHSHLGS EMFAAPMGRC AAGVMHLFYV RAGVSRAMLL RLFLAMEKGR HMEYECPYLV YVPVVAFRLE PKDGKGVFAV DGELMVSEAV QGQVHPNYFW MVSGCVEPPP SWKPQQMPPP EEPL
Klon 1D6
Isotyp IgG2a kappa
Kreuzreaktivität Human
Antigen
Andere Bezeichnung SPHK1 (SPHK1 Antibody Abstract)
Hintergrund Full Gene Name: sphingosine kinase 1
Synonyms: SPHK
Gen-ID 8877
Pathways VEGF Signaling
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Kommentare

Product Quality tested by: Antibody Reactive Against Recombinant Protein.

Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer In 1x PBS, pH 7.4
Handhabung Aliquot to avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C or lower. Aliquot to avoid repeated freezing and thawing.
Bilder des Herstellers
Image no. 1 for anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibody (ABIN522355) Detection limit for recombinant GST tagged SPHK1 is approximately 1ng/ml as a capture...
Image no. 2 for anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibody (ABIN522355) Western Blot analysis of SPHK1 expression in transfected 293T cell line by SPHK1 mono...
Image no. 3 for anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibody (ABIN522355) SPHK1 monoclonal antibody (M01), clone 1D6. Western Blot analysis of SPHK1 expression...
Image no. 4 for anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibody (ABIN522355) SPHK1 monoclonal antibody (M01), clone 1D6. Western Blot analysis of SPHK1 expression...
Produkt verwendet in: Sheu, Lee, Hua, Li, Lai, Lee, Cheng, Chen, Chan, Chao, Chen, Chang, Lee: "LRIG1 modulates aggressiveness of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling." in: Oncogene, Vol. 33, Issue 11, pp. 1375-84, 2014 (PubMed).

Böhm, Flößer, Ermler, Fender, Lüth, Kleuser, Schrör, Rauch: "Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells." in: Cardiovascular research, Vol. 99, Issue 3, pp. 505-13, 2013 (PubMed).

Zhang, Wang, Zhao, Di: "MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1." in: Journal of ovarian research, Vol. 6, Issue 1, pp. 84, 2013 (PubMed).

Schenten, Melchior, Steinckwich, Tschirhart, Bréchard: "Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9." in: Journal of leukocyte biology, Vol. 89, Issue 4, pp. 587-96, 2011 (PubMed).

Ali-Rahmani, Hengst, Connor, Schengrund: "Effect of HFE variants on sphingolipid expression by SH-SY5Y human neuroblastoma cells." in: Neurochemical research, Vol. 36, Issue 9, pp. 1687-96, 2011 (PubMed).

Asher, Warren, Shaw, Sowter, Bali, Khan: "The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line." in: Cancer cell international, Vol. 11, pp. 6, 2011 (PubMed).

Schröder, Richter, Juan, Maltusch, Giegold, Quintini, Pfeilschifter, Huwiler, Radeke: "The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen." in: Molecular immunology, Vol. 48, Issue 9-10, pp. 1139-48, 2011 (PubMed).

Sinha, Schorn, Hochstim, Chinn, Zhu, Masood: "Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition." in: Head & neck, Vol. 33, Issue 2, pp. 178-88, 2011 (PubMed).

Wang, Zhang, Lin, Xu, Feng, Ding: "A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart." in: Glycobiology, Vol. 20, Issue 4, pp. 473-84, 2010 (PubMed).

Billich, Urtz, Reuschel, Baumruker: "Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells." in: The international journal of biochemistry & cell biology, Vol. 41, Issue 7, pp. 1547-55, 2009 (PubMed).

in: , 1970 (PubMed).

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