Sphingosine Kinase 1 (SPHK1) (AA 1-384) Antikörper

Details zu Produkt Nr. ABIN522355
Antigen
Epitop
AA 1-384
35
14
14
10
10
8
8
7
7
4
4
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
184
76
69
14
4
4
2
2
1
1
1
1
1
1
Wirt
Maus
182
8
7
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
9
7
5
5
5
5
4
4
4
4
4
4
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
133
59
58
41
16
13
13
8
7
5
3
2
1
Optionen
Verwendungszweck Mouse monoclonal antibody raised against a full length recombinant SPHK1.
Immunogen

immunogen: SPHK1 (AAH08040, 1 a.a. ~ 384 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Immunogen Sequence: MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLLLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL

Klon 1D6
Isotyp IgG2a kappa
Kreuzreaktivität Human
Antigen
Andere Bezeichnung SPHK1 (SPHK1 Antibody Abstract)
Hintergrund Full Gene Name: sphingosine kinase 1
Synonyms: SPHK
Gen-ID 8877
Pathways VEGF Signaling
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Kommentare

Product Quality tested by: Antibody Reactive Against Recombinant Protein.

Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer In 1x PBS, pH 7.4
Handhabung Aliquot to avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Bilder des Herstellers
Image no. 1 for anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibody (ABIN522355) Detection limit for recombinant GST tagged SPHK1 is approximately 1ng/ml as a capture...
Image no. 2 for anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibody (ABIN522355) Western Blot analysis of SPHK1 expression in transfected 293T cell line by SPHK1 mono...
Image no. 3 for anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibody (ABIN522355) SPHK1 monoclonal antibody (M01), clone 1D6. Western Blot analysis of SPHK1 expression...
Image no. 4 for anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibody (ABIN522355) SPHK1 monoclonal antibody (M01), clone 1D6. Western Blot analysis of SPHK1 expression...
Produkt verwendet in: Sheu, Lee, Hua, Li, Lai, Lee, Cheng, Chen, Chan, Chao, Chen, Chang, Lee: "LRIG1 modulates aggressiveness of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling." in: Oncogene, Vol. 33, Issue 11, pp. 1375-84, 2014 (PubMed).

Böhm, Flößer, Ermler, Fender, Lüth, Kleuser, Schrör, Rauch: "Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells." in: Cardiovascular research, Vol. 99, Issue 3, pp. 505-13, 2013 (PubMed).

Zhang, Wang, Zhao, Di: "MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1." in: Journal of ovarian research, Vol. 6, Issue 1, pp. 84, 2013 (PubMed).

Schenten, Melchior, Steinckwich, Tschirhart, Bréchard: "Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9." in: Journal of leukocyte biology, Vol. 89, Issue 4, pp. 587-96, 2011 (PubMed).

Ali-Rahmani, Hengst, Connor, Schengrund: "Effect of HFE variants on sphingolipid expression by SH-SY5Y human neuroblastoma cells." in: Neurochemical research, Vol. 36, Issue 9, pp. 1687-96, 2011 (PubMed).

Asher, Warren, Shaw, Sowter, Bali, Khan: "The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line." in: Cancer cell international, Vol. 11, pp. 6, 2011 (PubMed).

Schröder, Richter, Juan, Maltusch, Giegold, Quintini, Pfeilschifter, Huwiler, Radeke: "The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen." in: Molecular immunology, Vol. 48, Issue 9-10, pp. 1139-48, 2011 (PubMed).

Sinha, Schorn, Hochstim, Chinn, Zhu, Masood: "Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition." in: Head & neck, Vol. 33, Issue 2, pp. 178-88, 2011 (PubMed).

Wang, Zhang, Lin, Xu, Feng, Ding: "A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart." in: Glycobiology, Vol. 20, Issue 4, pp. 473-84, 2010 (PubMed).

Billich, Urtz, Reuschel, Baumruker: "Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells." in: The international journal of biochemistry & cell biology, Vol. 41, Issue 7, pp. 1547-55, 2009 (PubMed).

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