TAB2 Antikörper (Middle Region)
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- Target Alle TAB2 Antikörper anzeigen
- TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TAB2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- SGSSQSSAHS QYNIQNISTG PRKNQIEIKL EPPQRNNSSK LRSSGPRTSS
- Produktmerkmale
- This is a rabbit polyclonal antibody against TAB2. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of Human TAB2
- Top Product
- Discover our top product TAB2 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
- Andere Bezeichnung
- TAB2 (TAB2 Produkte)
- Synonyme
- CHTD2 antikoerper, MAP3K7IP2 antikoerper, 1110030N06Rik antikoerper, A530078N03Rik antikoerper, Map3k7ip2 antikoerper, mKIAA0733 antikoerper, map3k7ip2 antikoerper, zgc:77446 antikoerper, TGF-beta activated kinase 1/MAP3K7 binding protein 2 antikoerper, TAB2 antikoerper, Tab2 antikoerper, tab2 antikoerper
- Hintergrund
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The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.
Alias Symbols: TAB2, KIAA0733, MAP3K7IP2,
Protein Interaction Partner: UBC, PIAS3, UBE2I, TRAF6, SUMO2, IRAK1, MAP3K7, TRIM38, SIK1, SIK3, TRIM22, NPM1, CST9L, SLC19A3, env, TAB1, NUMBL, IKBKG, FOSL1, ZBTB16, YWHAZ, VIM, TGM2, PPP2CB, IKBKB, GTF2I, FN1, HSP90AA1, BST2, MALT1, WDR34, APP, ESR1, MAP3K8, AR, TRIM5, TBL1XR1, MBD
Protein Size: 536 - Gen-ID
- 23118
- Pathways
- T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
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