PIP5K1A Antikörper (Middle Region)

Produktnummer ABIN5516131

Produktdetails anti-PIP5K1A Antikörper

Target: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIP5K1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GGKNIRIVVM NNLLPRSVKM HIKYDLKGST YKRRASQKER EKPLPTFKDL

Produktmerkmale: This is a rabbit polyclonal antibody against PIP5K1A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human PIP5K1A

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PIP5K1A

Target: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Andere Bezeichnung: PIP5K1A (PIP5K1A Produkte)

Synonyme: Pip5k1b antikoerper, pip5k1c antikoerper, PIP5K1A antikoerper, pip5k1b antikoerper, Pipk5a antikoerper, Pipk5b antikoerper, pip5k1a antikoerper, zgc:110576 antikoerper, im:7140933 antikoerper, zgc:158838 antikoerper, phosphatidylinositol-4-phosphate 5-kinase type 1 alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b antikoerper, PIP5K1A antikoerper, Pip5k1a antikoerper, pip5k1a.L antikoerper, pip5k1a antikoerper, pip5k1aa antikoerper, pip5k1ab antikoerper

Hintergrund: PIP5K1A catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation.

Alias Symbols: Name=PIP5K1A,

Protein Interaction Partner: UBC, ITGB1BP2, HECW2, UBD, SIRT1, CSNK1A1, APP, PIP5KL1, CADPS, PLD2, PLD1, CASP3, TEC, ARF6, BTK, ARF5, ARF1,

Protein Size: 562

Gen-ID: 8394

UniProt: Q99755

Pathways: PI3K-Akt Signalweg, Mitotic G1-G1/S Phases, Inositol Metabolic Process, DNA Replication, Cell-Cell Junction Organization, Synthesis of DNA