PIP5K1A Antikörper (N-Term)

Produktnummer ABIN6264231

Produktdetails anti-PIP5K1A Antikörper

Target: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIP5K1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: PIP5K1A Antibody detects endogenous levels of total PIP5K1A.

Homologie: Pig,Bovine,Sheep,Rabbit

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PIP5K1A, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PIP5K1A

Target: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Andere Bezeichnung: PIP5K1A (PIP5K1A Produkte)

Synonyme: Pip5k1b antikoerper, pip5k1c antikoerper, PIP5K1A antikoerper, pip5k1b antikoerper, Pipk5a antikoerper, Pipk5b antikoerper, pip5k1a antikoerper, zgc:110576 antikoerper, im:7140933 antikoerper, zgc:158838 antikoerper, phosphatidylinositol-4-phosphate 5-kinase type 1 alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b antikoerper, PIP5K1A antikoerper, Pip5k1a antikoerper, pip5k1a.L antikoerper, pip5k1a antikoerper, pip5k1aa antikoerper, pip5k1ab antikoerper

Hintergrund:

Description: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.

Gene: PIP5K1A

Molekulargewicht: 62 kDa

Gen-ID: 8394

UniProt: Q99755

Pathways: PI3K-Akt Signalweg, Mitotic G1-G1/S Phases, Inositol Metabolic Process, DNA Replication, Cell-Cell Junction Organization, Synthesis of DNA