PIP5K1A Antikörper (AA 293-562)

Produktnummer ABIN7163185

Produktdetails anti-PIP5K1A Antikörper

Target: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Bindungsspezifität: AA 293-562

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIP5K1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha protein (293-562AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PIP5K1A

Target: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Andere Bezeichnung: PIP5K1A (PIP5K1A Produkte)

Synonyme: Pip5k1b antikoerper, pip5k1c antikoerper, PIP5K1A antikoerper, pip5k1b antikoerper, Pipk5a antikoerper, Pipk5b antikoerper, pip5k1a antikoerper, zgc:110576 antikoerper, im:7140933 antikoerper, zgc:158838 antikoerper, phosphatidylinositol-4-phosphate 5-kinase type 1 alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b antikoerper, PIP5K1A antikoerper, Pip5k1a antikoerper, pip5k1a.L antikoerper, pip5k1a antikoerper, pip5k1aa antikoerper, pip5k1ab antikoerper

Hintergrund:

Background: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.

Aliases: 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha antibody, Phosphatidylinositol 4 phosphate 5 kinase type I alpha antibody, Phosphatidylinositol-4-phosphate 5-kinase type I alpha antibody, Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha antibody, PI4P5K Ia antibody, PI51A_HUMAN antibody, PIP5K A antibody, PIP5K1-alpha antibody, Pip5k1a antibody, PIP5KIalpha antibody, PtdIns(4)P-5-kinase 1 alpha antibody

UniProt: Q99755

Pathways: PI3K-Akt Signalweg, Mitotic G1-G1/S Phases, Inositol Metabolic Process, DNA Replication, Cell-Cell Junction Organization, Synthesis of DNA