CISH Antikörper (Middle Region)

Produktnummer ABIN5515903

Produktdetails anti-CISH Antikörper

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CISH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RILAFPDVVS LVQHYVASCT ADTRSDSPDP APTPALPMPK EDAPSDPALP

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CISH

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CISH

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Andere Bezeichnung: CISH (CISH Produkte)

Synonyme: CISH antikoerper, cis antikoerper, cish.a antikoerper, ptk9l antikoerper, twf1l antikoerper, wu:fk57g04 antikoerper, zgc:154062 antikoerper, zgc:91817 antikoerper, g18 antikoerper, socs antikoerper, cis-1 antikoerper, cish antikoerper, BACTS2 antikoerper, CIS antikoerper, CIS-1 antikoerper, G18 antikoerper, SOCS antikoerper, AI385595 antikoerper, CIS1 antikoerper, Cis antikoerper, F17 antikoerper, F23 antikoerper, cytokine inducible SH2 containing protein antikoerper, cytokine inducible SH2-containing protein antikoerper, CISH antikoerper, cish antikoerper, Cish antikoerper

Hintergrund: The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: CIS, G18, SOCS, CIS-1, BACTS2

Protein Size: 275

Gen-ID: 1154

NCBI Accession: NM_013324, NP_037456

UniProt: Q9NSE2

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus