CISH Antikörper (AA 241-258)

Produktnummer ABIN3030694

Produktdetails anti-CISH Antikörper

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Bindungsspezifität: AA 241-258

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CISH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Amino acids 241-258 (LPLPRRMADYLRQYPFQL) were used as the immunogen for this CISH antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the CISH antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the CISH antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu CISH

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Andere Bezeichnung: CISH (CISH Produkte)

Synonyme: CISH antikoerper, cis antikoerper, cish.a antikoerper, ptk9l antikoerper, twf1l antikoerper, wu:fk57g04 antikoerper, zgc:154062 antikoerper, zgc:91817 antikoerper, g18 antikoerper, socs antikoerper, cis-1 antikoerper, cish antikoerper, BACTS2 antikoerper, CIS antikoerper, CIS-1 antikoerper, G18 antikoerper, SOCS antikoerper, AI385595 antikoerper, CIS1 antikoerper, Cis antikoerper, F17 antikoerper, F23 antikoerper, cytokine inducible SH2 containing protein antikoerper, cytokine inducible SH2-containing protein antikoerper, CISH antikoerper, cish antikoerper, Cish antikoerper

Hintergrund: Cytokine inducible SH2-containing protein, also called CIS, CIS-1, G18, SOCS, is an important negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling (SOCS) family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria. The human gene is mapped to chromosome 3p21.3 by FISH. The mouse gene is tightly linked to the Gnai2 gene on chromosome 9, a region syntenic to human chromosome 3p21. CISH expression was upregulated by lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, and this upregulation involved downregulation of MIR98 and LET7, which relieved MIR98- and LET7-mediated translational repression of CISH. Gain- and loss-of-function studies showed that CISH accelerated degradation of IKBA and enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure.

UniProt: Q9NSE2

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus