DIO3 Antikörper (Middle Region)

Produktnummer ABIN5515229

Produktdetails anti-DIO3 Antikörper

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIO3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EVELNSEGEE VPPDDPPICV SDDNRLCTLA SLKAVWHGQK LDFFKQAHEG

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DIO3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DIO3

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Andere Bezeichnung: DIO3 (DIO3 Produkte)

Synonyme: 5DIII antikoerper, DIOIII antikoerper, txdi3 antikoerper, dioiii antikoerper, XL-15 antikoerper, itdi3 antikoerper, D3 antikoerper, TXDI3 antikoerper, iodothyronine deiodinase 3 antikoerper, deiodinase, iodothyronine, type 3 antikoerper, deiodinase, iodothyronine, type III antikoerper, deiodinase, iodothyronine type III antikoerper, deiodinase, iodothyronine, type 3 L homeolog antikoerper, DIO3 antikoerper, dio3 antikoerper, Dio3 antikoerper, dio3.L antikoerper

Hintergrund: The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Alias Symbols: D3, 5DIII, TXDI3, DIOIII,

Protein Size: 278

Gen-ID: 1735

NCBI Accession: NM_001362, NP_001353

UniProt: P55073

Pathways: Hormone Activity