DIO3 Produkte
(Deiodinase, Iodothyronine, Type III (DIO3))
Kategorien
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008].
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Ausgewählte DIO3 Kategorien
DIO3 Antikörper
High quality antibodies with extensive validation data.
DIO3 ELISA Kits
Reliable ELISA kits for a wide range of species.
DIO3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene DIO3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Applikation
WB, IHC, IP, ICC
Validierungen
- (5)
Kat. Nr.
ABIN7436198
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Rat
Applikation
WB, IHC, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN653482
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p)
Validierungen
- (3)
Kat. Nr.
ABIN750883
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene DIO3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966309
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966308
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6955331
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene DIO3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1351611
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1777658
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN3127568
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren DIO3 Produkten
: "Reduced Skeletal Muscle Protein Turnover and Thyroid Hormone Metabolism in Adaptive Thermogenesis That Facilitates Body Fat Recovery During Weight Regain." in: Frontiers in endocrinology, Vol. 10, pp. 119, (2019) (PubMed).: "Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes." in: JCI insight, Vol. 4, Issue 18, (2019) (PubMed).
: "A thyroid hormone network exists in synovial fibroblasts of rheumatoid arthritis and osteoarthritis patients." in: Scientific reports, Vol. 9, Issue 1, pp. 13235, (2019) (PubMed).
: "Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans." in: Endocrine, Vol. 59, Issue 2, pp. 353-363, (2018) (PubMed).
: "Caloric restriction induces energy-sparing alterations in skeletal muscle contraction, fiber composition and local thyroid hormone metabolism that persist during catch-up fat upon refeeding." in: Frontiers in physiology, Vol. 6, pp. 254, (2015) (PubMed).
: "Thyroid hormone inactivation in gastrointestinal stromal tumors." in: The New England journal of medicine, Vol. 370, Issue 14, pp. 1327-34, (2014) (PubMed).
: "Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis." in: Endocrinology, Vol. 155, Issue 8, pp. 3160-71, (2014) (PubMed).
: "Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis." in: Endocrinology, Vol. 155, Issue 10, pp. 4061-8, (2014) (PubMed).
: "Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity." in: The Biochemical journal, Vol. 453, Issue 1, pp. 71-82, (2013) (PubMed).
: "Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 44, pp. 17232-46, (2013) (PubMed).
Synonyme und alternative Namen zu DIO3
iodothyronine deiodinase 3 (DIO3), deiodinase, iodothyronine, type 3 (dio3), deiodinase, iodothyronine, type III (dio3), deiodinase, iodothyronine type III (Dio3), deiodinase, iodothyronine, type 3 L homeolog (dio3.L), iodothyronine deiodinase 3 (Dio3), 5DIII, D3, DIOIII, dioiii, itdi3, txdi3, TXDI3, XL-15Bezeichner auf Proteinebene für DIO3
- type III iodothyronine deiodinase
- Type 3 DI
- Type-III 5'-deiodinase
- type 3 iodothyronine deiodinase
- deiodinase, iodothyronine, type III
- gene 15
- type 3 deiodinase
- iodothyronine 5-deiodinase type III
- 5DIII
- DIOIII
- type 3 DI
- type-III 5'-deiodinase
- deiodinase, iodothyronine, type 3
- iodothyronine deiodinase, placental type
- thyroxine deiodinase type III (selenoprotein)
- type 3 iodothyronine selenodeiodinase
- type-III 5' deiodinase
- iodothyronine deiodinase type III
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