DIS3 Produkte
(Exosome Complex Exonuclease RRP44 (DIS3))
Kategorien
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities (By similarity).
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Ausgewählte DIS3 Kategorien
DIS3 Antikörper
High quality antibodies with extensive validation data.
DIS3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene DIS3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (3)
Kat. Nr.
ABIN524836
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (1)
- (2)
Kat. Nr.
ABIN524835
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p)
Validierungen
- (2)
Kat. Nr.
ABIN654155
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene DIS3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6228991
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene DIS3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1351629
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3137036
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3095104
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren DIS3 Produkten
: "Global analysis of the nuclear processing of transcripts with unspliced U12-type introns by the exosome." in: Nucleic acids research, Vol. 42, Issue 11, pp. 7358-69, (2014) (PubMed).: "Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target." in: Nucleic acids research, Vol. 42, Issue 2, pp. 1270-90, (2014) (PubMed).
: "Mammalian 5'-capped microRNA precursors that generate a single microRNA." in: Cell, Vol. 155, Issue 7, pp. 1568-80, (2013) (PubMed).
: "The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control." in: Molecular and cellular biology, Vol. 11, Issue 12, pp. 5839-47, (1991) (PubMed).
Synonyme und alternative Namen zu DIS3
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (Dis3), DIS3 exosome endoribonuclease and 3'-5' exoribonuclease (dis3), DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (dis3.L), 2810028N01Rik, bA555G22.1, DIS3, dis3, dis3p, EXOSC11, KIAA1008, RGD1304646, RP11-342J4.3, RRP44, wu:fb08g12Bezeichner auf Proteinebene für DIS3
- 2810028N01Rik
- exosome complex exonuclease RRP44
- exosome component 11
- mitotic control protein dis3 homolog
- protein DIS3 homolog
- ribosomal RNA-processing protein 44
- DIS3 mitotic control homolog (S. cerevisiae)
- DIS3 mitotic control homolog
- DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
- DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
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