DIO3 Antikörper (C-Term)

Produktnummer ABIN951914

Produktdetails anti-DIO3 Antikörper

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Bindungsspezifität: AA 249-278, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIO3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes Human DIO3 (C-term).

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 249~278 amino acids from the C-terminal region of human DIO3

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu DIO3

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Andere Bezeichnung: DIO3 (DIO3 Produkte)

Synonyme: 5DIII antikoerper, DIOIII antikoerper, txdi3 antikoerper, dioiii antikoerper, XL-15 antikoerper, itdi3 antikoerper, D3 antikoerper, TXDI3 antikoerper, iodothyronine deiodinase 3 antikoerper, deiodinase, iodothyronine, type 3 antikoerper, deiodinase, iodothyronine, type III antikoerper, deiodinase, iodothyronine type III antikoerper, deiodinase, iodothyronine, type 3 L homeolog antikoerper, DIO3 antikoerper, dio3 antikoerper, Dio3 antikoerper, dio3.L antikoerper

Hintergrund: DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.Synonyms: 5DIII, DIOIII, ITDI3, TXDI3, Type 3 DI, Type III iodothyronine deiodinase, Type-III 5'-deiodinase

Molekulargewicht: 31451 Da

Gen-ID: 1735

NCBI Accession: NP_001353

Pathways: Hormone Activity