c-MET Antikörper (pTyr1234)

Produktnummer ABIN498738

Produktdetails anti-c-MET Antikörper

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Bindungsspezifität: pTyr1234

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser c-MET Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects endogenous levels of Met protein only when phosphorylated at Tyr1234

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH ~7.2, 0.05 % sodium azide

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Andere Bezeichnung: HGF Receptor (MET Produkte)

Synonyme: AUTS9 antikoerper, HGFR antikoerper, RCCP2 antikoerper, c-Met antikoerper, AI838057 antikoerper, HGF antikoerper, Par4 antikoerper, Hgfr antikoerper, c-met antikoerper, MET antikoerper, C-MET antikoerper, met antikoerper, met-A antikoerper, MET proto-oncogene, receptor tyrosine kinase antikoerper, met proto-oncogene antikoerper, MET proto-oncogene, receptor tyrosine kinase L homeolog antikoerper, MET antikoerper, Met antikoerper, met.L antikoerper

Hintergrund: The c-Met oncogene was originally isolated from a chemical carcinogen-treated human osteogenic sarcoma cell line by transfection analysis in NIH/3T3 cells. The Met protooncogene product was identified as a transmembrane receptorlike protein with tyrosine kinase activity that is expressed in many tissues. A high proportion of spontaneous NIH/3T3 transformants overexpress c-Met and by transfection analysis the c-Met proto-oncogene has been shown to exhibit transforming activity.Tyrosine phosphorylation of apparently normal Met protein has also been observed in certain human gastric carcinoma cell lines. Tyrosine phosphorylation enhances the receptor kinase activity, while serine phosphorylation of Met on residue 985 has an inhibitory effect. The c-Met gene product has been identified as the cell surface receptor for hepatocyte growth factor, a plasminogen-like protein thought to be a humoral mediator of liver regeneration.Synonyms: HGF/SF receptor, Hepatocyte growth factor receptor, MET, Met proto-oncogene tyrosine kinase, Scatter factor receptor, c-Met

Molekulargewicht: approx. 170 kDa

Gen-ID: 4233

NCBI Accession: NP_000236

UniProt: P08581

Pathways: RTK Signalweg, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor