SKP1 Antikörper

Produktnummer ABIN498169

Produktdetails anti-SKP1 Antikörper

Target: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Skp1 p19 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography using epitope-specific immunogen

Reinheit: > 95 % (by SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu SKP1

Target: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Andere Bezeichnung: SKP1 / OCP2 (SKP1 Produkte)

Synonyme: EMC19 antikoerper, OCP-II antikoerper, OCP2 antikoerper, SKP1A antikoerper, TCEB1L antikoerper, p19A antikoerper, 15kDa antikoerper, 2610043E24Rik antikoerper, 2610206H23Rik antikoerper, SKP1 antikoerper, Tceb1l antikoerper, p19Skp1 antikoerper, Skp1a antikoerper, skp1a antikoerper, zgc:73186 antikoerper, ocp2 antikoerper, emc19 antikoerper, ocp-ii antikoerper, tceb1l antikoerper, ARABIDOPSIS SKP1 HOMOLOGUE 1 antikoerper, ASK1 antikoerper, ATSKP1 antikoerper, S phase kinase-associated protein 1 antikoerper, T4O12.17 antikoerper, T4O12_17 antikoerper, UFO INTERACTING PROTEIN 1 antikoerper, UIP1 antikoerper, ocp-2 antikoerper, S-phase kinase associated protein 1 antikoerper, S-phase kinase-associated protein 1 antikoerper, S-phase kinase-associated protein 1 pseudogene antikoerper, S-phase kinase-associated protein 1A antikoerper, S-phase kinase-associated protein 1 S homeolog antikoerper, S phase kinase-associated protein 1 antikoerper, SKP1 antikoerper, skp1 antikoerper, LOC100340043 antikoerper, Skp1a antikoerper, Skp1 antikoerper, skp1.S antikoerper

Hintergrund: The critical role that the family of regulatory proteins known as cyclins plays in eukaryotic cell cycle regulation is well established. The best characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of MPF (maturation promoting factor). Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DP-1 and E2F and retinoblastoma protein p110. Two cyclin A-Cdk2 complex binding proteins, Skp1 p19 and Skp2 p45, have been described. Although the Skps (S phase kinase-associated proteins) associate with the active cyclin A-Cdk2 complex, they do not exhibit any regulatory effects on the complex. Abolition of Skp2 p45 function by either microinjection of anti-p45 antibodies or addition of antisense oligonucleotides prevents entry into S phase of both normal and transformed cells.Synonyms: Cyclin A/CDK2-associated protein p19, EMC19, OCP-2, OCP-II, Organ of Corti protein 2, RNA polymerase II elongation factor-like protein, S-phase kinase-associated protein 1, SKP1A, TCEB1L, Transcription elongation factor B, p19A, p19skp1

Molekulargewicht: approx. 19 kDa

Gen-ID: 6500

NCBI Accession: NP_008861

UniProt: P63208

Pathways: Zellzyklus, Hedgehog Signalweg, Mitotic G1-G1/S Phases