PTPN1 Antikörper

Produktnummer ABIN3032393

Produktdetails anti-PTPN1 Antikörper

Target: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Purified

Immunogen: This PTP1B antibody was produced from rabbits immunized with a recombinant protein encoding aa 1~321 of human PTP1B.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the PTP1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the PTP1B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu PTPN1

Target: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Andere Bezeichnung: PTP1B (PTPN1 Produkte)

Synonyme: PTPN1 antikoerper, PTP1B antikoerper, PTP-1B antikoerper, PTP-HA2 antikoerper, Ptp antikoerper, ptp1b antikoerper, wu:fk54h03 antikoerper, CPTP1 antikoerper, protein tyrosine phosphatase, non-receptor type 1 antikoerper, protein tyrosine phosphatase, non-receptor type 1 L homeolog antikoerper, PTPN1 antikoerper, Ptpn1 antikoerper, ptpn1 antikoerper, ptpn1.L antikoerper

Hintergrund: PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

UniProt: P18031

Pathways: TLR Signalweg, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling