PTPN1 Antikörper (N-Term)

Produktnummer ABIN1882122

Dieses Anti-PTPN1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PTPN1 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 6+ Publikationen zitiert.

Kurzübersicht für PTPN1 Antikörper (N-Term) (ABIN1882122)

Target: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB7011

Produktdetails anti-PTPN1 Antikörper

Bindungsspezifität: AA 23-53, N-Term

Homologie: M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PTP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-53 amino acids from the N-terminal region of human PTP1B.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PTPN1 Antikörper (ABIN1882122)

Trümpler, Schlott, Herrlich, Greer, Böhmer: "Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B." in: The FEBS journal, Vol. 276, Issue 19, pp. 5622-33, (2009) (PubMed).

Xu, Li, Qian, Hong, Shen, Huang: "Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter." in: Biochemical and biophysical research communications, Vol. 329, Issue 2, pp. 538-43, (2005) (PubMed).

Blincoe, Chidambaram, Salari, Bond, Evans, Gray-Kaufman, Griffey, Tranby, Garner-Johnson, Lee, Sorenson: "Pharmacokinetic distribution of 67Cu(II)2[3,5-diisopropyl(carboxy-14C)salicylate]4 among murine tissues." in: Current medicinal chemistry, Vol. 11, Issue 22, pp. 3007-15, (2004) (PubMed).

Wiesmann, Barr, Kung, Zhu, Erlanson, Shen, Fahr, Zhong, Taylor, Randal, McDowell, Hansen: "Allosteric inhibition of protein tyrosine phosphatase 1B." in: Nature structural & molecular biology, Vol. 11, Issue 8, pp. 730-7, (2004) (PubMed).

Kipfer-Coudreau, Eberlé, Sahbatou, Bonhomme, Guy-Grand, Froguel, Galan, Basdevant, Clément: "Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects." in: Diabetologia, Vol. 47, Issue 7, pp. 1278-84, (2004) (PubMed).

Palmer, Bento, Mychaleckyj, Langefeld, Campbell, Norris, Haffner, Bergman, Bowden: "Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study." in: Diabetes, Vol. 53, Issue 11, pp. 3013-9, (2004) (PubMed).

Details zu PTPN1

Target: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Andere Bezeichnung: PTP1B

Hintergrund: PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Molekulargewicht: 49967

NCBI Accession: NP_001265547, NP_002818

UniProt: P18031

Pathways: TLR Signalweg, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling