TRIM29 Antikörper (Internal Region)

Produktnummer ABIN401461

Produktdetails anti-TRIM29 Antikörper

Target: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Makake, Schimpanse

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM29 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts with over-expressed, acetylated lysine ATDC protein.

Kreuzreaktivität (Details): Species reactivity (expected):Horse, Cattle, Chimpanzee, Macaque, Mouse, Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Peptide corresponding to an internal portion of human ATDC protein around lysine 116

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/100,000. Western Blot: 1/500 - 1/3,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.67 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu TRIM29

Target: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Andere Bezeichnung: TRIM29 / ATDC (TRIM29 Produkte)

Synonyme: ATDC antikoerper, 1110047J21Rik antikoerper, 2810431N19Rik antikoerper, 4732461M22Rik antikoerper, AI119726 antikoerper, MGC53484 antikoerper, TRIM29 antikoerper, atdc antikoerper, tripartite motif containing 29 antikoerper, tripartite motif-containing 29 antikoerper, tripartite motif containing 29 L homeolog antikoerper, TRIM29 antikoerper, Trim29 antikoerper, trim29.L antikoerper, trim29 antikoerper

Hintergrund: Ataxiatelangiectasia group D-associated protein (ATDC), also called tripartite motif-containing protein 29 (TRIM29), is a novel Histone deacetylase (HDAC) associated protein. Its function is tightly regulated by HDAC. ATDC Lysine 116 (K116) is acetylated and has a significant functional role in regulating cell survival and tumorigenesis. ATDC is expressed in placenta, prostate and thymus, and is over expressed in pancreatic and cervical tumors. Its function in tumor cells is not fully understood. It is constitutively phosphorylated by PKC on serine/threonine in A431 cells. The ATDC gene product is one of a group of proteins that share multiple zinc finger motifs and an adjacent leucine zipper motif. These proteins have been proposed to form homo- or heterodimers involved in nucleic acid binding, consistent with the fact that many of these proteins appear to be transcriptional regulatory factors involved in carcinogenesis and/or differentiation. The likelihood that the ATDC gene product is involved in transcriptional regulation could explain the pleiomorphic characteristics of AT, including abnormal cell cycle regulation.Synonyms: Ataxia-telangiectasia group D-associated protein, Tripartite motif-containing protein 29

Gen-ID: 23650

NCBI Accession: NP_036233

UniProt: Q14134

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus