TRIM29 Antikörper (AA 1-200)

Produktnummer ABIN6939434

Produktdetails anti-TRIM29 Antikörper

Target: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Bindungsspezifität: AA 1-200

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TRIM29 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Coating (Coat), Staining Methods (StM)

Spezifität: It recognizes a 66 kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90 % positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment (126 Amino acid residues between aa 1-200) of human TRIM29 protein

Klon: TRIM29-1041

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Human tonsil or squamous cell carcinoma.

Known Application: ELISA (For coating, order Ab without BSA), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu TRIM29

Target: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Andere Bezeichnung: TRIM29 (TRIM29 Produkte)

Synonyme: ATDC antikoerper, 1110047J21Rik antikoerper, 2810431N19Rik antikoerper, 4732461M22Rik antikoerper, AI119726 antikoerper, MGC53484 antikoerper, TRIM29 antikoerper, atdc antikoerper, tripartite motif containing 29 antikoerper, tripartite motif-containing 29 antikoerper, tripartite motif containing 29 L homeolog antikoerper, TRIM29 antikoerper, Trim29 antikoerper, trim29.L antikoerper, trim29 antikoerper

Molekulargewicht: 66kDa

Gen-ID: 23650

UniProt: Q14134

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus