IFT57 Antikörper (Internal Region)

Produktnummer ABIN375157

Produktdetails anti-IFT57 Antikörper

Target: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser IFT57 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to HIPPI.

Kreuzreaktivität (Details): Species reactivity (expected):Rat, Bovine.
Species reactivity (tested):Human, Mouse.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-EQPQEYDDPNATISN, from the internal region of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/8000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu IFT57

Target: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Andere Bezeichnung: HIP1-Interacting Protein (IFT57 Produkte)

Synonyme: Esrrbl1 antikoerper, 4833420A15Rik antikoerper, Hippi antikoerper, MHS4R2 antikoerper, ESRRBL1 antikoerper, HIPPI antikoerper, intraflagellar transport 57 antikoerper, intraflagellar transport 57 S homeolog antikoerper, Ift57 antikoerper, IFT57 antikoerper, ift57.S antikoerper

Hintergrund: HIPPI was identified as a protein that interacts with HIP1 (Huntingtin-interacting protein 1). HIPPI mRNA is expressed in the brain. It is present in all regions of the brain, and to a lesser extent in spinal cord. It is also expressed abundantly in heart, kidney, and lung, with weaker expression in all other tissues tested. HIPPI is expressed in the Golgi apparatus of neurons where it partly colocalizes with HIP1. HIPPI forms a heterodimer with HIP1. The availability of free HIP1 is modulated by polyglutamine length within huntingtin, with disease-associated polyglutamine expansion favoring the formation of proapoptotic HIPPI-HIP1 heterodimers. These heterodimers can recruit procaspase-8 into a complex of HIPPI, HIP1, and procaspase-8 and launch apoptosis through components of the extrinsic cell death pathway. This novel non-receptor-mediated pathway for activating caspase-8 might contribute to neuronal death in Huntington disease.Synonyms: DERP8, Dermal papilla-derived protein 8, ESRRBL1, Estrogen-related receptor beta-like protein 1, HIPPI, IFT57, Intraflagellar transport protein 57 homolog, MHS4R2

Gen-ID: 55081, 9606

UniProt: Q9NWB7

Pathways: Hedgehog Signalweg, Positive Regulation of Endopeptidase Activity