IFT57 Antikörper

Produktnummer ABIN7247168

Produktdetails anti-IFT57 Antikörper

Target: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFT57 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of human IFT57

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:300, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.5 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu IFT57

Target: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Andere Bezeichnung: IFT57 (IFT57 Produkte)

Synonyme: Esrrbl1 antikoerper, 4833420A15Rik antikoerper, Hippi antikoerper, MHS4R2 antikoerper, ESRRBL1 antikoerper, HIPPI antikoerper, intraflagellar transport 57 antikoerper, intraflagellar transport 57 S homeolog antikoerper, Ift57 antikoerper, IFT57 antikoerper, ift57.S antikoerper

Hintergrund: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator, however the relevance of such function remains unclear.

UniProt: Q9NWB7

Pathways: Hedgehog Signalweg, Positive Regulation of Endopeptidase Activity