FE65 Antikörper (C-Term)

Produktnummer ABIN374723

Produktdetails anti-FE65 Antikörper

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser FE65 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to APBB1 / FE65.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-GSLKPKRLGAHTP, from the C Terminus of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/128000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FE65

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Andere Bezeichnung: APBB1 / FE65 (APBB1 Produkte)

Synonyme: FE65 antikoerper, MGC:9072 antikoerper, RIR antikoerper, apbb1 antikoerper, MGC80654 antikoerper, Fe65 antikoerper, Rir antikoerper, amyloid beta precursor protein binding family B member 1 antikoerper, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog antikoerper, amyloid beta (A4) precursor protein-binding, family B, member 1 antikoerper, APBB1 antikoerper, apbb1.L antikoerper, Apbb1 antikoerper

Hintergrund: Amyloid precursor protein (APP), which plays a central role in the pathogenesis of Alzheimer's disease (AD), is a cell-surface protein that is cleaved by gamma-secretase at the transmembrane region into an extracellular amyloid-beta peptide (Ab) and an intracellular tail fragment. This cytoplasmic tail of APP forms a multimeric complex with the nuclear adaptor protein FE65 and the histone acetyltransferase Tip60.1 FE65 is an adaptor protein that bridges APP to certain molecular pathways. FE65 is also highly expressed in neurons and possesses the characteristics of a transcription factor. The interaction between APP and FE65 increases the translocation of APP to the cell surface and the subsequent secretion of Ab. FE65 is thus important in the regulation and trafficking of APP.Synonyms: Amyloid beta A4 precursor protein-binding family B member 1, RIR

Gen-ID: 322, 9606

UniProt: O00213

Pathways: Positive Regulation of Response to DNA Damage Stimulus